Xenium streamlines spatial biology experiments, providing a map of gene expression patterns without conventional sequencing. The design prioritizes ergonomics, resulting in a swing door for an improved user experience, a tilted display for easy usability, and a status bar above for a clear view of the machine's behavior. The design language focused on simplicity, timelessness, and reliability, with subtle surface treatments and accent colors for user guidance. Internally, the reagent bottle assembly was optimized for efficiency, incorporating color cues and a removable spill containment tray.